Chengdu Pukang Biotechnology Co., Ltd.

Global supplier of high-quality reagents

We offer a range of high-quality reagents, including small
molecular PEG, long-acting drugs, and polypeptide molecular
building blocks.

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PEG derivatives

High purity PEG derivatives from PEG1-PEG36 and related quality report are provided.

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Fatty acid modified side chain block

We can provide high quality peptide Long acting drug modified side chains and their intermediates.

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Linkers

We could provide different antibody-drugconjugate linkers to help the medicine
development.

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About us

16 +

Years

1000 +

Customers

5000 +

Products

Chengdu Pukang Biotechnology Technology Co., Ltd. (hereinafter referred to as Pukang) was established in 2008. For more than ten years, it has been focusing on the research and development, production and sales of polypeptide modify side chains and single-molecule PEG (referred to as small molecule PEG) derivatives, has built small molecule PEG derivatives block library.

Pukang provides the best CDMO service to customers worldwide d on its R&D capabilities and state-of-the-art facilities. Pukang aims to be the best partner in realizing customer-tailored services through skilled professionals and top-notch facilities. We want to share our experience in developing and producing products in the fastest and highest quality manner through optimized routes with healthcare companies around the world.

Pukang has built a polypeptide long-acting modifier platform, which can not only provide hundreds of different types of peptide long-acting side chain molecules, but also provide high-quality long-acting side chain design services, quality research and CDE documents; Long-acting side chains can be used for GLP-1, GCP and anti-HIV drugs to improve half-life and enhance patient compliance. The company has developed and produced a series of multi-category, novel structures, high-quality long-acting polypeptide side chains for many companies around the world, mainly including aliphatic alkane series, MIPA series and cholesterol series products. Molecular block of long-acting peptide side chain helps customers to quickly realize the molecular screening and evaluation of innovative peptide drugs. In order to meet the needs of customers in the development of new drugs and commercialization stage, we have a 3,000-square-meter R&D a 2,000-square-meter pilot-scale laboratory and a 60,000-square-meter production that meets GMP requirements.

Pukang is deeply engaged in small molecule PEG derivatives, using single molecular weight PEG for drug delivery series, and establishing single molecular weight liposome molecular block which can use for nucleic acid drug siRNA delivery to improve drug stability and prolong half-life. Liposomes with a single molecular weight PEG can improve the quality of products, reduce the side effects caused by impurities, and reduce the difficulty of impurity research.

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Explore our products

Specialising in PEG derivatives and PEGylation services

GLP-1 analog intermediates

Chengdu Pukang is one of the most professional manufacturers for GLP-1 analog intermediates, featured by good quality control, and competitive price. We usually have available goods in stock and can provide from grams to kgs through cold chain logistics for transportation. External modification of side chain is one of the important technologies for long-acting peptides. Pukang has established a peptide long-acting modification platform to provide multiple varieties of modified side chains and side chain fragments, which helps drug development and accelerates the industrialization of pharmaceuticals. We have these Long-acting peptide side chain varieties：Semaglutide side chain (DMF Filing No.039906); Tirzepatide side chain (DMF Filing No. 039989); Insulin Degludec side chain; Icodec insulin side chain; Liraglutide side chain; Long-acting growth hormone side chain; Other customized sidechains and their blocks; Side-chain modifiers are one of the important factors in the pharmacokinetic behavior of peptide products. The development and production of side-chain modifiers of Pukang are carried out in accordance with the requirements of ICH Q11 and other relevant guidelines. According to its structural characteristics and preparation process, potential impact on the quality of peptide drugs, etc., we carry out perfect impurity profiling research and control to ensure the effectiveness and safety of peptide drugs. Semaglutide side chain and Tirzepatide side chain had completed the process verification (50kg) and accumulated dozens of batches, the quality between batches is stable, and the impurity spectrum is consistent.

Other long-actting peptide modifiers

Chengdu Pukang is one of the most professional manufacturers for other long acting polypeptide modifiers with good quality and better price. We usually have available goods in stock and can provide from grams to kgs through cold chain logistics for transportation. Long acting side chains can be used for GLP-1, GCP, and anti HIV drugs to increase half-life and enhance patient compliance. Mainly including fatty alkane series, MIPA series, and cholesterol series products. Long acting peptide side chain molecular blocks help customers quickly achieve innovative peptide drug molecular screening and evaluation. Long chain fatty acids have a carbon atom number greater than 12 on their carbon chain. Most foods contain long-chain fatty acids. Fatty acids can be divided into three categories on the difference between saturated and unsaturated hydrocarbon chains, which includes saturated fatty acids, with no unsaturated bonds on hydrocarbons，monounsaturated fatty acids have an unsaturated bond in their hydrocarbon chain and polyunsaturated fatty acids have two or more unsaturated bonds in their hydrocarbon chains.

Single small molecule PEG

Chengdu Pukang is one of the most professional manufacturers for Single small molecule PEG with good quality and better price. The monodisperse PEGs supplied by Pukang all have strict control over their congeners. Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible, non-toxic, and immunogenic polymer used for drug modification. PEG modification technology has the following advantages: ·Enhance stability and extend drug half-life. ·Improve pharmacodynamic properties and reduce known toxicity. ·Improve solubility of insoluble drugs. ·Improve the distribution of drugs in the body, improve pharmacokinetic properties. Monodisperse PEG, the molecular weight is clear, is a single compound, compared to polydisperse PEG has obvious advantages. According to the requirements of ICHQ3A and ICHQ11, the impurity spectrum control of monodisperse PEG derivatives is one of the important evidences to fully demonstrate the effectiveness and safety of drugs. The monodisperse PEGs supplied by Pukang all have strict control over their congeners. The introduction of different end groups of PEG materials can give PEG excellent properties. At present, monodisperse PEG derivatives are used in the fields of peptide, XDC (ADC\RDC\PDC)-Linker, drug delivery and so on. According to the different end groups, Pukang has designed and prepared many series of PEG derivatives, and most of the products have been realized to be produced in 10 kg. We can also customize and assist in the design of different types of PEG derivatives upon request. Polyethylene glycol, abbreviated as PEG, is a high molecular polymer formed by the polymerization of ethylene glycol. It has multiple forms such as single chain polyethylene glycol, branched polyethylene glycol, and multi arm polyethylene glycol, which has good water solubility. It also has good solubility with many organic components. PEG modification of proteins and peptide drugs can prolong the half-life of drugs, reduce immunogenicity, and preserve their biological activity as much as possible. The mechanism is that after PEG chemical modification of the protein, the modifier couples with the protein molecule, resulting in an increase in the molecular weight of the protein and a change in its spatial structure. PEG will not be degraded before it is cleared. The barrier effect of PEG protects proteins from being easily degraded by proteases, while reducing the production of antibodies. When the molecular weight of the modified protein reaches or exceeds the minimum value of glomerular filtration, the protein can escape glomerular filtration after entering the kidney with blood circulation, thus staying in the blood circulation for a longer time. Modified PEG can also be used as excipients in drug delivery systems.

Long-chain fatty acid series

Chengdu Pukang is one of the most professional manufacturers for long chain fatty acid with good quality and better price. We can provide different kinds of long chain fatty acid with homologues control. Long chain fatty acids have a carbon atom number greater than 12 on their carbon chain. Most foods contain long-chain fatty acids. Fatty acids can be divided into three categories on the difference between saturated and unsaturated hydrocarbon chains, which includes saturated fatty acids, with no unsaturated bonds on hydrocarbons，monounsaturated fatty acids have an unsaturated bond in their hydrocarbon chain and polyunsaturated fatty acids have two or more unsaturated bonds in their hydrocarbon chains.

AEEA Series Molecular Blocks

Chengdu Pukang is one of the most professional manufacturers for AEEA series with good quality and better price. We have more than 10 years experience for producing AEEA and now the batch size can reach 200kg per batch.AEEA is a single component product, with minimal ethylenediamine impurity. The product is water-soluble, clear, colorless, and slightly viscous. An ammonia-like odor is typical of the product. Can be used for long acting peptide side chains and PEGs.

Advanced Pharmaceutical Excipients

Chengdu Pukang is one of the most professional manufacturers for SNAC with good quality and better price. As regular product usually available in stock.The English name of a raw material drug is API (Active Pharmaceutical Ingredients), which refers to the active ingredients of a drug and are the fundamental substances that constitute its pharmacological effects. Raw materials cannot be directly used by patients and must be further processed into formulations through the addition of excipients and other processes before patients can take them. Intermediates are a type of material produced in the process steps of an API that must undergo further molecular changes or refinement to become an API. The broad industry of raw materials includes APIs and intermediates. SNAC is the absorption enhancer of semaglutide tablets. It is an N-acetylated amino acid derivative synthesized from salicylic acid, which is weakly acidic and amphiphilic. SNAC is the only penetration enhancer approved to improve oral absorption. In other preclinical studies, SNAC has the effect of improving the penetration of peptides (such as insulin) in the intestine. Semaglutide tablets containing SNAC are placed in different volumes of simulated gastric juice, and the pH value gradually changes from acidic to neutral. The smaller the volume, the more obvious the buffering effect; on the contrary, the SNAC-free Semaglutide tablets have no significant effect on the pH value of simulated gastric juice .In view of the significant buffering effect of SNAC, the effect of pH on the stability of semaglutide was investigated in in the presence of pepsin.

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Solutions for your needs

We can provide one-stop service from customer's order to delivery

Registration Support

Product CMC data writing(ICH M4Q)
Demonstration of impurity removal with downstream customers
Research and reply to official comments

Registration Support

Production support

Capacity support for customer commercialization scale
Acceptance of new varieties of customized servicesCustomized product specifications and quality standards

Production support

New drug R&D support

Design of novel modifications
Provide a variety of different blocks to accelerate screening
Assist in the development of synthesis technology of Hugh's reagent EULA