Chengdu Pukang is one of the most professional manufacturers for Single small molecule PEG with good quality and better price. The monodisperse PEGs supplied by Pukang all have strict control over their congeners. Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible, non-toxic, and immunogenic polymer used for drug modification. PEG modification technology has the following advantages: ·Enhance stability and extend drug half-life. ·Improve pharmacodynamic properties and reduce known toxicity. ·Improve solubility of insoluble drugs. ·Improve the distribution of drugs in the body, improve pharmacokinetic properties. Monodisperse PEG, the molecular weight is clear, is a single compound, compared to polydisperse PEG has obvious advantages. According to the requirements of ICHQ3A and ICHQ11, the impurity spectrum control of monodisperse PEG derivatives is one of the important evidences to fully demonstrate the effectiveness and safety of drugs. The monodisperse PEGs supplied by Pukang all have strict control over their congeners. The introduction of different end groups of PEG materials can give PEG excellent properties. At present, monodisperse PEG derivatives are used in the fields of peptide, XDC (ADC\RDC\PDC)-Linker, drug delivery and so on. According to the different end groups, Pukang has designed and prepared many series of PEG derivatives, and most of the products have been realized to be produced in 10 kg. We can also customize and assist in the design of different types of PEG derivatives upon request. Polyethylene glycol, abbreviated as PEG, is a high molecular polymer formed by the polymerization of ethylene glycol. It has multiple forms such as single chain polyethylene glycol, branched polyethylene glycol, and multi arm polyethylene glycol, which has good water solubility. It also has good solubility with many organic components. PEG modification of proteins and peptide drugs can prolong the half-life of drugs, reduce immunogenicity, and preserve their biological activity as much as possible. The mechanism is that after PEG chemical modification of the protein, the modifier couples with the protein molecule, resulting in an increase in the molecular weight of the protein and a change in its spatial structure. PEG will not be degraded before it is cleared. The barrier effect of PEG protects proteins from being easily degraded by proteases, while reducing the production of antibodies. When the molecular weight of the modified protein reaches or exceeds the minimum value of glomerular filtration, the protein can escape glomerular filtration after entering the kidney with blood circulation, thus staying in the blood circulation for a longer time. Modified PEG can also be used as excipients in drug delivery systems.