Fmoc-His-Aib-OH TFA (CAS 1446013-08-6): Key Applications in Therapeutic Development

Introduction

Fmoc-His-Aib-OH TFA (CAS 1446013-08-6) is a high-performance amino acid derivative widely utilized in peptide synthesis. While its chemical structure combines the Fmoc protecting group, histidine, α-aminoisobutyric acid (Aib), and trifluoroacetic acid (TFA), the true value of this compound lies in its ability to enable advanced therapeutic and biotechnological innovations. This article focuses on its transformative applications across drug discovery, nanotechnology, and biomaterials, emphasizing why CAS 1446013-08-6 is a cornerstone of modern biomedical research.

Core Applications of Fmoc-His-Aib-OH TFA

1. Designing Stable Therapeutic Peptides

The incorporation of Aib into peptides imparts structural rigidity, reducing enzymatic degradation and improving pharmacokinetics. For example:

Antimicrobial Peptides (AMPs): Aib-stabilized AMPs show prolonged activity against drug-resistant pathogens.
Anticancer Therapeutics: Peptides with Aib exhibit enhanced tumor-targeting efficiency and reduced off-target toxicity.
Hormone Mimetics: Aib-containing analogs of ghrelin or insulin demonstrate improved bolic stability.

2. Enabling mRNA and Nanoparticle Drug Delivery

Fmoc-His-Aib-OH TFA (CAS 1446013-08-6) plays a role in synthesizing ionizable lipids or peptide-d carriers for lipid nanoparticles (LNPs). These LNPs, critical for mRNA vaccines (e.g., COVID-19 vaccines), benefit from:

pH-Responsive Release: Histidine’s imidazole group aids endosomal escape, enhancing mRNA delivery efficiency.
Enhanced Biocompatibility: Aib’s rigidity stabilizes nanoparticle structures, improving circulation time.

3. Structural Biology and Drug Screening

X-ray/NMR Studies: Aib’s conformational constraints simplify peptide crystallization, enabling precise analysis of protein-ligand interactions.
High-Throughput Screening: Stable Aib-containing peptides serve as reliable tools for identifying enzyme inhibitors or receptor agonists.

4. Biomaterials and Industrial Catalysis

Enzyme Mimics: Histidine’s l-binding capacity allows the creation of artificial lloenzymes for green chemistry applications.
Smart Hydrogels: pH-sensitive peptides derived from Fmoc-His-Aib-OH TFA enable responsive drug release systems.

Advantages Over Conventional Amino Acids

Superior Stability: Aib minimizes peptide aggregation and proteolysis.
Scalability: Compatible with automated solid-phase peptide synthesis (SPPS) for industrial-scale production.
Versatility: Combines histidine’s functionality with Aib’s structural control.

Case Studies Highlighting Impact

COVID-19 mRNA Vaccines: LNPs using ionizable lipids rely on structurally stable helper components, a demand met by Aib-enhanced formulations.
Antimicrobial Coatings: Aib-rich peptides in medical devices reduce biofilm formation.
Targeted Cancer Therapy: Peptide-drug conjugates with Aib improve tumor selectivity and reduce systemic side effects.

Global Supplier Spotlight: Pukang Biotechnology

As a leader in peptide and lipid synthesis, Pukang Biotechnology supplies high-purity Fmoc-His-Aib-OH TFA (CAS 1446013-08-6) to support cutting-edge research. Services include:

Bulk Manufacturing: GMP-grade production for clinical-stage therapeutics.
Custom Lipid Design: Tailored ionizable lipids, PEGylated lipids, and phospholipids for nanoparticle formulations.
Technical Collaboration: Optimization of SPPS protocols for complex peptides.

Contact: +86-137-0808-4407 | export@pu-kang.com

Conclusion

Fmoc-His-Aib-OH TFA (CAS 1446013-08-6) transcends traditional peptide synthesis, driving breakthroughs in mRNA vaccines, antimicrobials, and precision medicine. Its unique blend of stability, functionality, and scalability makes it indispensable for researchers and pharmaceutical developers aiming to tackle global health challenges.