Introduction

Octadecanedioic Acid Mono-tert-Butyl Ester (CAS 843666-40-0) is a specialty ester derivative of octadecanedioic acid, widely recognized for its dual functionality as a long-chain dicarboxylic acid and a tert-butyl-protected carboxyl group. This compound serves as a critical intermediate in polymer chemistry, drug delivery systems, and advanced material engineering. Its CAS number, 843666-40-0, ensures unambiguous identification in research, industrial applications, and regulatory documentation. This article explores its chemical properties, applications, and advantages in modern synthetic workflows.

Chemical Structure and Key Features

Octadecanedioic Acid Mono-tert-Butyl Ester (CAS 843666-40-0) comprises:

1. Octadecanedioic Acid Backbone: An 18-carbon dicarboxylic acid providing hydrophobicity and structural flexibility.

2. tert-Butyl Ester Group: A bulky protecting group that masks one carboxyl group, enabling selective reactivity during synthesis.

3. Free Carboxylic Acid: The unprotected carboxyl group allows further functionalization or polymerization.

The CAS registry 843666-40-0 distinguishes this compound from similar esters, streamlining procurement and quality control.

Applications in Industry and Research

1. High-Performance Polymer Synthesis

• Polyamides and Polyesters: The long hydrocarbon chain enhances mechanical strength and thermal stability in engineering plastics.

• Biodegradable Materials: Used to synthesize eco-friendly polymers for packaging or biomedical implants.

2. Pharmaceutical Intermediate

• Prodrug Design: The tert-butyl ester acts as a hydrolyzable prodrug moiety, enabling controlled drug release.

• Lipid Nanoparticles (LNPs): Incorporated into lipid formulations for mRNA or siRNA delivery, improving stability and cellular uptake.

3. Surfactants and Lubricants

• The amphiphilic structure (hydrophobic chain + polar carboxyl group) makes it suitable for industrial surfactants or lubricant additives.

4. Coating and Adhesive Technologies

• Enhances adhesion and flexibility in epoxy resins or polyurethane coatings.

Advantages Over Compounding Alternatives

• Selective Reactivity: The tert-butyl group allows stepwise deprotection under acidic conditions (e.g., trifluoroacetic acid), enabling precise synthesis control.

• Thermal Stability: Withstands high-temperature polymerization processes without decomposition.

• Scalability: Compatible with batch and continuous-flow manufacturing for industrial-scale production.

Synthesis and Handling

Synthesis Protocol:

1. Esterification: Octadecanedioic acid reacts with tert-butanol in the presence of a catalyst (e.g., H₂SO₄) to form the mono-ester.

2. Purification: Isolated via column chromatography or recrystallization.

Storage Recommendations:

• Store in cool, dry conditions (4–8°C) to prevent hydrolysis.

• Protect from moisture and strong acids/s.

Safety and Regulatory Compliance

• Handling: Wear gloves and goggles to avoid skin/eye irritation.

• Disposal: Follow local regulations for organic ester waste.

• Regulatory Status: Listed under CAS 843666-40-0, classified as non-hazardous with standard lab precautions.

Global Supplier: Pukang Biotechnology

Pukang Biotechnology supplies high-purity Octadecanedioic Acid Mono-tert-Butyl Ester (CAS 843666-40-0) alongside custom synthesis services for tailored derivatives. Their offerings include:

• Bulk Quantities: GMP-compliant production for pharmaceutical and industrial use.

• Technical Expertise: Support for polymerization or prodrug development projects.

• Fast Global Delivery: Ensuring seamless integration into R&D and manufacturing pipelines.

Contact: +86-137-0808-4407 | export@pu-kang.com

Conclusion

Octadecanedioic Acid Mono-tert-Butyl Ester (CAS 843666-40-0) bridges the gap between organic chemistry and industrial innovation, enabling breakthroughs in polymers, drug delivery, and sustainable materials. Its unique combination of hydrophobicity, selective protection, and synthetic versatility makes it indispensable for researchers and engineers aiming to develop next-generation technologies.