Key Features

Dual Methylated Pseudopeptide Modification：ψ(Me,Me)Pro substitution enhances bolic stability by 60% vs. natural peptide bonds, resisting protease degradation.

Fmoc & Side Chain Protection：Orthogonal deprotection for SPPS, with Fmoc protecting the amino group and tBu-like groups on Ser (customizable per synthesis needs).

High Purity Profile：Single impurity ≤0.3%, total impurities ≤1.0% (COA with HPLC/NMR/MS data available).

Applications

Protease Inhibitor Development：

Critical for designing HIV-1 protease inhibitors (e.g., darunavir analogs) by stabilizing β-turn structures, improving binding affinity by 35%.

Resists enzymatic cleavage in serum, extending half-life for parenteral formulations (e.g., subcutaneous injections).

GLP-1 Agonist Engineering：

Enhances receptor binding in long-acting GLP-1 analogs for diabetes/obesity, reducing dosing frequency through pseudopeptide rigidity.

Improves bolic stability in vivo, maintaining activity for ≥72 hours post-administration.

Biomedical Research：

Model compound for studying GPCR-ligand interactions (e.g., CXCR4 receptor antagonists for cancer therapy).

Enables isotopic labeling (¹³C, ¹⁵N) for NMR-d structure-activity relationship (SAR) studies.

Manufacturing Standards

GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis (≥99% ee).

Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical-stage projects (available upon request).

Stability Testing：Validated for 24 months at -20°C, with no degradation under accelerated conditions (60°C, 90% RH for 14 days).

Services Offered

Structural Modifications：

Alternative protection groups (Boc, Cbz) for orthogonal deprotection.

Isotopic labeling (¹³C, ²H) at Phe/Ser or ψ(Me,Me)Pro for PK/PD studies.

Scalable Production：

100 mg to 5 kg batches, with process validation for GMP-grade materials (≥98.5% purity).

Technical Consultation：

Free peptide design support by PhD-level chemists, specializing in pseudopeptide conformation analysis.

Company Profile

15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.

R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.

Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.

Contact Us

Email：export@pu-kang.com

Phone：+86-137-0808-4407

Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.