Global high-quality reagent supplier
CAS:878797-09-2
DMF Num:878797-09-2
Pseudopeptide Backbone Modification：ψ(Me,Me)Pro substitution enhances bolic stability by 60% vs. natural peptide bonds, resisting protease degradation.
Dual Protection System：Fmoc (amino protection) and tBu (tyrosine hydroxyl protection) enable orthogonal deprotection in SPPS.
High Purity Profile：Single impurity ≤0.3%, total impurities ≤1.0%.
GLP-1 Agonist Development：
Critical for synthesizing long-acting GLP-1 analogs (e.g., Semaglutide derivatives) by stabilizing β-turn structures, extending half-life by 35%.
Improves receptor binding affinity by 40% compared to unmodified peptides, reducing dosing frequency.
Protease Inhibitor Synthesis：
Used in HIV protease inhibitor design (e.g., darunavir analogs) to enhance target engagement and resist enzymatic cleavage.
Biomedical Research：
Enables isotopic labeling (¹³C, ¹⁵N) for NMR-d structure-activity relationship (SAR) studies.
Models for cell-penetrating peptide (CPP) development with enhanced membrane permeability.
GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis.
Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical-stage projects.
Stability Testing：Validated for 24 months at -20°C, with no degradation under accelerated conditions (60°C, 90% RH for 14 days).
Structural Modifications：
Alternative protection groups (Boc, Cbz) for orthogonal deprotection.
Isotopic labeling (¹³C, ²H) at Tyr/Ser or ψ(Me,Me)Pro for PK/PD studies.
Scalable Production：
100 mg to 5 kg batches, with process validation for GMP-grade materials (≥98.5% purity).
Technical Consultation：
Free peptide design support by PhD-level chemists, specializing in pseudopeptide conformation analysis.
15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.
R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.
Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.
Email：export@pu-kang.com
Phone：+86-137-0808-4407
Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
PuKang Inc.
Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
Tel : +8613708084407
Business/Technical Consulting：
Tel : 008628-82550498 Tel : +8613708084407Order/Customer Service Email：
export@pu-kang.com celeste@pu-kang.com
+8613708084407
