Key Features

Multi-Protection System：Boc, Trt, and OBtu groups enable orthogonal deprotection for complex peptide assembly.

Aib Residue：Enhances backbone rigidity, improving bolic stability in long-acting peptides.

Functional Motif：His-Glu sequence supports pH-sensitive binding and l ion coordination.

Applications

Semaglutide Intermediate：Critical for constructing the His-Aib-Glu motif in Semaglutide's amino acid sequence, improving coupling efficiency by 20% in SPPS.

Peptide Drug Development：Facilitates synthesis of GLP-1 agonists for diabetes/obesity treatment, with Aib enhancing half-life by 35%.

Structural Biology：Enables studies on peptide-receptor interactions, with Glu(OBtu) enabling pH-dependent activity modulation.

Manufacturing Standards

GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC.

Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation upon request.

Stability Testing：Validated for 24 months under -20°C dry storage.

Analytical Data

1890228-73-5 HNMR

1890228-73-5 LCMS

Services Offered

Custom Modifications：Alternative protection groups (e.g., Boc, Cbz) or isotopic labeling (¹³C, ¹⁵N) for PK studies.

Scalable Production：100 mg to 10 kg batches, supporting from R&D to commercial manufacturing.

Technical Consultation：Free peptide design support by our PhD-level chemistry team.

Company Profile

15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.

R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.

Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.

Contact Us

Email：export@pu-kang.com

Phone：+86-137-0808-4407

Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.