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Fmoc-Lys(Pal-Glu-OtBu)-OH (CAS 1491158-62-3) is an important peptide intermediate for synthesizing high-quality peptides. Learn more about its properties, applications, and how it supports efficient drug discovery. Visit Chengdu Pukang Biotechnology for top-quality peptide products.
1. Introduction to Fmoc-Lys(Pal-Glu-OtBu)-OH (CAS 1491158-62-3)
Fmoc-Lys(Pal-Glu-OtBu)-OH (CAS 1491158-62-3) is a key peptide intermediate used in peptide synthesis. It features an Fmoc protective group on lysine, which is crucial for avoiding unwanted reactions. The addition of Pal-Glu-OtBu makes it more soluble and stable. This compound is essential for creating peptides with precise sequences for various research applications, including drug discovery and diagnostics.
2. Structural Insights
The structure of Fmoc-Lys(Pal-Glu-OtBu)-OH includes:
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Fmoc group: Protects the amino group on lysine.
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Lysine: A critical amino acid for building peptide chains.
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Palmitoyl group (Pal): Enhances solubility, especially in hydrophobic environments.
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Glutamic acid (Glu) with OtBu ester: Increases stability, allowing for controlled peptide synthesis.
This structure makes the compound more versatile and easier to work with compared to other similar peptides, which is why it’s favored in complex peptide synthesis.
3. Mechanism of Action and Research Advancements
How It Works:
In solid-phase peptide synthesis (SPPS), Fmoc-Lys(Pal-Glu-OtBu)-OH ensures that lysine remains protected during peptide elongation. The palmitoyl group helps the peptide dissolve better in solvents, which is essential for peptides that are tough to dissolve. The Glu-OtBu ester acts as a switch, making it reactive only when needed.
Research Advancements:
Recent studies have shown that peptides made using Fmoc-Lys(Pal-Glu-OtBu)-OH have better stability and bioactivity. Researchers have begun using this compound in targeted therapies, including cancer and autoimmune disease treatments. Its ability to form more stable and specific peptide structures opens doors to more precise therapeutic approaches.
4. Solubility and Storage Recommendations
Solubility:
Fmoc-Lys(Pal-Glu-OtBu)-OH dissolves well in organic solvents like DMF and DMSO. To improve solubility, some users heat the solution or mix it with other solvents.
Storage:
Store the compound in a cool, dry place, away from light and moisture. To ensure stability, it should be kept in a sealed container under an inert gas like nitrogen.
5. Applications in Peptide Synthesis
Fmoc-Lys(Pal-Glu-OtBu)-OH is a key tool in synthesizing custom peptides for therapeutic and research purposes. It helps create peptides that are used in drug discovery, diagnostics, and various biological studies. Thanks to its unique properties, it is particularly useful in synthesizing peptides that need high stability and specificity.
6. Why Choose Chengdu Pukang Biotechnology
Chengdu Pukang Biotechnology is dedicated to providing high-quality peptide intermediates, including Fmoc-Lys(Pal-Glu-OtBu)-OH. Our products meet rigorous standards and are supported by comprehensive technical specifications to ensure consistent quality and reliable results. For more information on our offerings, visit our product page:
Fmoc-Lys(Pal-Glu-OtBu)-OH - Chengdu Pukang Biotechnology
7. Conclusion
Fmoc-Lys(Pal-Glu-OtBu)-OH (CAS 1491158-62-3) is a crucial peptide intermediate that simplifies peptide synthesis and enhances peptide stability. Its unique structure and properties make it ideal for drug development and targeted therapies. For researchers and pharmaceutical companies, this compound offers reliability, versatility, and superior performance.
For more details on Fmoc-Lys(Pal-Glu-OtBu)-OH, visit the product page at Chengdu Pukang Biotechnology.
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