Global high-quality reagent supplier
CAS:1491158-62-3
DMF Num:1491158-62-3
Strategic Protection System：
Fmoc group for orthogonal amino protection in SPPS.
OtBu protection on Glu ensures selective deprotection during Liraglutide synthesis.
Palmitoyl (C16) Lipid Tail：Enhances albumin binding, extending peptide half-life by 300% in vivo.
High Purity Profile：Single impurity ≤0.3%, total impurities ≤1.0% (COA with HPLC/NMR/MS data available).
Liraglutide Side Chain Modification：
Critical for introducing the palmitoyl-glutamate moiety at Lys26, enabling albumin binding and 24-hour sustained activity.
Improves receptor binding affinity by 40% compared to unmodified peptides, reducing dosing frequency to daily.
Long-Acting Peptide Development：
Used in GLP-1 agonist analogs for type 2 diabetes/obesity, mimicking natural GLP-1's glucose-lowering effect with enhanced stability.
Lipid tail facilitates self-assembly into micelles, optimizing formulation stability for injectable delivery.
Biomedical Research：
Models for studying lipid-peptide interactions in drug delivery systems.
Supports isotopic labeling (¹³C, ¹⁵N) for NMR-d pharmacokinetic studies.
GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis (≥99% ee).
Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical-stage projects.
Stability Testing：Validated for 24 months at 2-8°C, with no degradation under accelerated conditions (40°C, 75% RH for 14 days).
Structural Modifications：
Alternative fatty acid chains (C14-C18), isotopic labeling (¹³C, ²H) for PK/PD studies.
Custom protection groups (Boc, Cbz) for orthogonal deprotection strategies.
Scalable Production：
100 mg to 5 kg batches, with process validation for GMP-grade materials (≥98.5% purity).
Technical Consultation：
Free synthetic route design by PhD-level chemists, specializing in lipid-peptide conjugation.
15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.
R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.
Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.
Email：export@pu-kang.com
Phone：+86-137-0808-4407
Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
PuKang Inc.
Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
Tel : +8613708084407
Business/Technical Consulting：
Tel : 008628-82550498 Tel : +8613708084407Order/Customer Service Email：
export@pu-kang.com celeste@pu-kang.com
+8613708084407
