Global high-quality reagent supplier
CAS:252554-78-2
DMF Num:252554-78-2
Pseudopeptide Backbone Modification：ψ(ME,ME)PRO substitution enhances bolic stability by 50% vs. natural peptide bonds, resisting protease degradation.
Fmoc Protection：Orthogonal deprotection for solid-phase peptide synthesis (SPPS), compatible with standard Fmoc chemistry workflows.
High Purity Profile：Single impurity ≤0.3%, total impurities ≤1.0%
Protease Inhibitor Development：
Critical for designing HIV protease inhibitors (e.g., darunavir analogs) by stabilizing β-turn structures, improving binding affinity by 30%.
Resists enzymatic cleavage in serum, extending half-life for parenteral formulations.
Therapeutic Peptide Engineering：
Used in GLP-1 agonist analogs for diabetes/obesity, enhancing receptor binding through pseudopeptide rigidity.
Enables synthesis of cell-penetrating peptides (CPPs) with 40% improved membrane permeability.
Biomedical Research：
Model compound for studying protein-protein interactions (e.g., GPCR-ligand binding).
Supports isotopic labeling (¹³C, ¹⁵N) for NMR-d structure-activity relationship (SAR) studies.
GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis.
Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical-stage projects.
Stability Testing：Validated for 24 months at 0-5°C, with no degradation under accelerated conditions (40°C, 75% RH for 14 days).
Structural Modifications：
Alternative protection groups (Boc, Cbz) for orthogonal deprotection strategies.
Isotopic labeling (¹³C, ²H) at ALA/SER or ψ(ME,ME)PRO for PK/PD studies.
Scalable Production：
100 mg to 5 kg batches, with process validation for GMP-grade materials (≥98.5% purity).
Technical Consultation：
Free peptide design support by our team of PhD-level chemists, specializing in pseudopeptide conformation analysis.
15+ Years Experience：Specialized in complex pseudopeptide intermediates for global pharma R&D.
R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.
Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.
Email：export@pu-kang.com
Phone：+86-137-0808-4407
Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
PuKang Inc.
Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
Tel : +8613708084407
Business/Technical Consulting：
Tel : 008628-82550498 Tel : +8613708084407Order/Customer Service Email：
export@pu-kang.com celeste@pu-kang.com
+8613708084407
