Fmoc-His-Aib-OH TFA, CAS number 1446013-08-6 is a versatile compound in peptide chemistry, offering researchers a tool to design and synthesize peptides with tailored structural and functional properties. Its integration into solid-phase peptide synthesis facilitates the creation of novel peptide analogs for various biochemical and pharmaceutical applications.The following are specific applications：

1. Solid-Phase Peptide Synthesis (SPPS)：

1）Methodology：SPPS involves sequentially coupling protected amino acids onto a resin-bound peptide chain.

Coupling：Fmoc-His-Aib-OH TFA(CAS number 1446013-08-6) is utilized as a building block in this process.

2）Deprotection：Fmoc deprotection is achieved using treatment (typically piperidine), exposing the amino group of the incorporated residue for subsequent coupling.

2. Peptide Design：

1）Structural Features：Incorporation of Aib enhances peptide rigidity and stability due to its unique side chain characteristics.

2）Functionality：Histidine residues may confer pH sensitivity or l binding capabilities to the synthesized peptides.

3. Research Applications：

1）Biochemistry and Pharmacology：Peptides synthesized using Fmoc-His-Aib-OH TFA(CAS number 1446013-08-6) can be used to study protein-protein interactions, enzyme mechanisms, or as potential therapeutic agents.

2）Structure-Activity Relationship (SAR) Studies：Testing peptide analogs to optimize biological activity and specificity.

4. Practical Considerations：

1）Handling：Requires standard peptide synthesis equipment and techniques.

2）Purification：Typically involves HPLC purification post-synthesis to isolate and characterize the desired peptide product.

3）Characterization：Analytical techniques such as mass spectrometry and NMR spectroscopy confirm peptide sequence and purity.

Fmoc-His-Aib-OH TFA(CAS number 1446013-08-6) is utilized as a building block in solid-phase peptide synthesis. It allows for the controlled addition of histidine and Aib residues to growing peptide chains. The Fmoc group protects the amino group during synthesis, while TFA helps in deprotection and purification steps. This compound is useful in designing peptides with specific sequences and enhanced structural stability.