Boc-His(Trt)-Aib-OH, CAS number 2061897-68-3, a highly specialized peptide synthesis reagent employed within the biomedical industry, presents a powerful capability for the creation of peptide sequences inclusive of unconventional amino acids. Boc-L-His(Trt)-Aib-OH(CAS number 2061897-68-3) is used as a building block in the synthesis of peptides and proteins, particularly when there is a need to protect certain functional groups during the synthesis process. The combination of protecting groups (Boc and Trt) and the Aib residue allows chemists to precisely control peptide synthesis, which is crucial for creating peptides with specific sequences and functional properties.Its steadfast utilization helps to promote the generation of distinct and optimal peptide architectures, critical for the progression of targeted drug development, including the likes of Alzheimer's disease, cancer and many other diseases.

The compound Boc-L-His(Trt)-Aib-OH(CAS number 2061897-68-3) is commonly applied to the Peptide Synthesis and Design、Research on Peptide Conformation and Stability、Medicinal Chemistry and Drug Development、Analytical and Structural Studies、Custom Peptide Libraries.The following are specific applications：

1. Peptide Synthesis and Design

1）Building Block in Solid-Phase Synthesis: This compound serves as a key building block for constructing peptides. The Boc and Trt groups protect the amino and side-chain functionalities of histidine and are selectively removed during the peptide assembly process.

2）Incorporating Rigid Structures: The α-aminoisobutyric acid (Aib) residue introduces rigidity into the peptide backbone. This rigidity can be crucial for stabilizing peptide structures, influencing folding patterns, and improving the peptide's biological activity or stability.

2. Research on Peptide Conformation and Stability

1）Studying Secondary Structures: By integrating Aib residues into peptides, researchers can study the impact of rigidity on peptide conformation. This can provide insights into how peptide chains fold and maintain structural stability.

2）Designing Peptide Mimetics: The incorporation of Aib and protected histidine residues can help in designing peptide mimetics that mimic natural peptides but with enhanced stability or altered biological activity.

3. Medicinal Chemistry and Drug Development

1）Developing Therapeutic Peptides: Peptides with modified structures, like those containing Boc-L-His(Trt)-Aib-OH(CAS number 2061897-68-3), can be used to design therapeutics with specific binding properties or improved pharmacokinetic profiles.

2）Peptide Inhibitors: Inhibitors designed using this building block can target specific enzymes or receptors, potentially leading to new treatments for various diseases.

4. Analytical and Structural Studies

NMR and X-ray Crystallography: Peptides synthesized with this building block can be used in structural studies to understand how specific amino acid sequences and modifications affect the overall structure and function of peptides.

5. Custom Peptide Libraries

Generating Peptide Libraries: This compound can be used to create peptide libraries for screening and identifying peptides with desired properties or biological activities.

In summary, Boc-L-His(Trt)-Aib-OH(CAS number 2061897-68-3) is a versatile compound in peptide chemistry, utilized for its ability to introduce specific structural features and protections in peptide synthesis. Its applications span from fundamental research in peptide structure and function to practical uses in drug development and therapeutic design.