Key Features

Dual Protection System：Boc (tert-butoxycarbonyl) and tBu (tert-butyl) groups enable orthogonal deprotection in peptide synthesis.

Aib Residue Integration：Enhances peptide backbone rigidity, improving bolic stability and target binding affinity.

Low Impurity Profile：Single impurity ≤0.5%, total impurities ≤1.0% (COA available upon request).

Applications

Tirzepatide Intermediate：Critical for constructing the Tyr-Aib motif in Tirzepatide (a dual GLP-1/GIP receptor agonist), improving coupling efficiency by 25% compared to standard tyrosine derivatives.

Peptide Drug Development：Suitable for synthesizing long-acting peptides for bolic disease treatment (e.g., obesity, type 2 diabetes).

Structural Biology Research：Aib-induced rigidity facilitates studies on peptide secondary structure and receptor binding mechanisms.

GMP-Compliant Facility：Produced in an ISO 9001:2015 certified plant with strict QC protocols.

Global Regulatory Support：Provides DMF, CE, and REACH registration documents for EU/US markets.

Stability Testing：Validated for 24 months under -20°C dry storage.

Services Offered

Custom Modifications：Alternative protection groups (e.g., Fmoc, Cbz) or isotopic labeling (¹³C, ¹⁵N) for mechanistic studies.

Scalable Production：Milligram to kilogram batches, supporting preclinical research to commercial manufacturing.

Technical Consultation：Free peptide synthesis optimization by our PhD-level chemistry team.

Company Profile

15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.

R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.

Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.

Contact Us

Email：export@pu-kang.com

Phone：+86-137-0808-4407

Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.