Explore Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH (CAS 1890228-73-5), a key compound in peptide synthesis. Learn about its structure, function, uses in drug development, and how to handle it. Discover related products from Chengdu Pukang Biotechnology.

1. What Is Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH?

Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH (CAS 1890228-73-5) is a special compound used in peptide synthesis. It’s made up of several amino acids with protective groups that make it stable during the synthesis process. This compound is important for creating peptides used in drug research, protein studies, and biotechnology.

The chemical formula is C24H31N3O6, and the compound’s main job is to be a building block for more complex peptides.

2. Chemical Structure

Let’s break down the key parts of this molecule:

• Boc (tert-butoxycarbonyl): This protects the amino group of histidine. It stops unwanted reactions during peptide chain growth.

• His(Trt): Histidine is important for many biological functions. The Trityl (Trt) group protects the imidazole ring of histidine.

• Aib (α-aminoisobutyric acid): This non-natural amino acid helps peptides fold in specific ways, adding stability.

• Glu(OBtu): Glutamic acid is an acidic amino acid. The OBtu protection keeps the carboxyl group safe during synthesis.

• Gly (Glycine): A simple amino acid that completes the peptide chain.

Each part of this structure is designed to help build stable, active peptides.

3. How Is It Used in Peptide Synthesis?

Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH is used in solid-phase peptide synthesis (SPPS). Here’s a simple overview of the process:

1. Activate: The carboxyl group of each amino acid is activated using reagents like HATU or DIC.

2. Couple: The activated amino acid attaches to the growing peptide chain.

3. Deprotect: After each addition, the Boc group is removed with TFA (trifluoroacetic acid) to reveal the amino group.

4. Repeat: This process continues until the full peptide is made.

The protective groups (like Boc and Trt) ensure that the peptide grows in the right order and doesn’t react in unwanted ways.

4. Why Is This Compound Important?

Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH plays a key role in creating peptides with high stability and precision. Peptides are often used to:

• Mimic proteins: Some peptides can mimic natural proteins and affect biological processes.

• Target diseases: Researchers use these peptides to design drugs that target diseases like cancer or infections.

• Create specific structures: Aib (α-aminoisobutyric acid) helps create peptides that fold in certain ways, which is important for their function.

By using this compound, researchers can create peptides that work better and are more stable.

5. Recent Research and Applications

Research is focusing on using Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH for:

• Cancer therapy: Peptides made from this compound may help target cancer cells.

• Antimicrobial treatments: It can be used to create peptides that fight resistant bacteria.

• Immunotherapy: Some peptides are designed to help the immune system recognize and fight tumors.

This compound is part of a growing field that’s looking at peptides as treatments for many different diseases.

6. Solubility and Storage

Here’s what you need to know about handling Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH:

• Solubility: It dissolves in organic solvents like DMSO, acetonitrile, and methanol, but not in water.

• Storage: Keep it in a dry, cool place, ideally at -20°C. This will help it stay stable.

Avoid exposing it to moisture or direct light, as it can break down.

7. Chengdu Pukang Biotechnology Products

At Chengdu Pukang Biotechnology, we offer a variety of peptide products, including Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH. Our products are made for research and development, helping scientists and companies create new peptides for drugs and therapies. Explore our full range of products at Chengdu Pukang Biotechnology – CAS 1890228-73-5.

8. Conclusion

In summary, Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH (CAS 1890228-73-5) is a crucial compound in peptide synthesis. It helps scientists create stable, functional peptides used in drug discovery and other biological research. Its unique structure and protective groups make it a reliable building block for a variety of applications in healthcare and biotechnology.

As peptide research continues to grow, compounds like Boc-His(Trt)-Aib-Glu(OBtu)-Gly-OH will become even more important in developing new treatments and therapies.

For more information on this compound and our peptide products, visit Chengdu Pukang Biotechnology – CAS 1890228-73-5.