Key Features

Dual tBu Protection：tBuO on Ste and OtBu on Glu enable orthogonal deprotection in Semaglutide synthesis.

AEEA Linker System：Two aminoethoxyethanoic acid (AEEA) units enhance hydrophilicity for improved solubility.

OSU Active Ester：Facilitates efficient coupling with amine-containing peptides, boosting reaction yield by 30%.

Applications

Semaglutide Side Chain Modification：

Critical for introducing the C18 fatty acid chain in Semaglutide, enhancing receptor binding and half-life (extended to 7 days in vivo).

Enables site-specific conjugation to the peptide backbone, improving bolic stability by 45%.

Long-Acting Peptide Development：

Used in synthesizing GLP-1 agonists for type 2 diabetes/obesity treatment, reducing dosing frequency.

AEEA linkers optimize pharmacokinetic properties, balancing lipophilicity and water solubility.

Peptide-Drug Conjugate (PDC) Research：

Models for developing fatty acid-conjugated peptides with enhanced cellular uptake.

Manufacturing Standards

GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC.

Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical trials.

Stability Testing：Validated for 24 months at -20°C.

Services Offered

Structural Modifications：

Alternative fatty acid chains (C16-C20), isotope labeling (¹³C, ²H) for PK studies.

Custom linker lengths (AEEA x1-x5) to optimize drug release kinetics.

Scalable Production：

100 mg to 10 kg batches, with process validation for GMP-grade materials.

Technical Consultation：

Free synthetic route optimization by our PhD-level peptide chemistry team.

Company Profile

15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.

R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.

Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.

Contact Us

Email：export@pu-kang.com

Phone：+86-137-0808-4407

Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.