Global high-quality reagent supplier
CAS:683239-16-9
DMF Num:683239-16-9
Long-Alkyl Chain Protection：tert-Butoxycarbonyl (Boc) group on the 20th carbon enables orthogonal deprotection in insulin analog synthesis.
C20 Fatty Acid Backbone：Linear alkyl chain with terminal carboxylic acid, ideal for lipid-peptide conjugation in long-acting insulin development.
High Purity Profile：Single impurity ≤0.3%, total impurities ≤1.0% (COA with HPLC/GC-MS/FT-IR data available).
Insulin Icodec Side Chain Modification：
Critical for introducing the C20 fatty acid moiety in Insulin Icodec, extending half-life to 7 days via albumin binding.
Enables site-specific conjugation at LysB29, improving bolic stability by 400% compared to unmodified insulin.
Long-Acting Insulin Development：
Used in synthesizing basal insulin analogs (e.g., degludec) for type 1/2 diabetes, reducing dosing frequency to once weekly.
Lipid chain facilitates self-association into multihexamers, enabling sustained subcutaneous release.
Peptide-Lipid Conjugate Research：
Models for developing fatty acid-conjugated peptides with enhanced cellular uptake and blood-brain barrier permeability.
GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis.
Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical-stage projects.
Stability Testing：Validated for 24 months at room temperature, with no degradation under accelerated conditions (40°C, 75% RH for 14 days).
Structural Modifications：
Alternative alkyl chains (C18-C22), isotopic labeling (¹³C, ²H) for PK/PD studies.
Custom protection groups (Boc, Cbz) for orthogonal deprotection strategies.
Scalable Production：
100 g to 10 kg batches, with process validation for GMP-grade materials (≥98.5% purity).
Technical Consultation：
Free synthetic route optimization by our PhD-level organic chemistry team (24-hour response).
15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.
R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.
Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.
Email：export@pu-kang.com
Phone：+86-137-0808-4407
Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
PuKang Inc.
Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
Tel : +8613708084407
Business/Technical Consulting：
Tel : 008628-82550498 Tel : +8613708084407Order/Customer Service Email：
export@pu-kang.com celeste@pu-kang.com
+8613708084407
