Global high-quality reagent supplier
CAS:1662688-20-1
DMF Num:1662688-20-1
Multifunctional Protection System：
Fmoc protection on N-terminal Lys for orthogonal deprotection in SPPS.
Dual otBu groups on Glu and Oct chain enable sequential cleavage during peptide synthesis.
AEEA Linker Architecture：Two aminoethoxyethanoic acid units enhance hydrophilicity, improving solubility by 50% in aqueous buffers.
Long-Alkyl Chain Modification：Octyl (C8) chain facilitates lipid-like interactions, critical for albumin binding in long-acting peptides.
Semaglutide Side Chain Conjugation：
Essential for introducing the fatty acid moiety in Semaglutide, extending half-life to 7 days via albumin binding.
Enables site-specific modification at Lys26, improving receptor binding affinity by 40%.
Long-Acting Peptide Development：
Used in GLP-1 agonist analogs for diabetes/obesity, reducing dosing frequency from daily to weekly.
AEEA linkers balance lipophilicity and water solubility, optimizing pharmacokinetic properties.
Peptide-Drug Conjugate (PDC) Engineering：
Models for developing fatty acid-conjugated peptides with enhanced cellular uptake and bolic stability.
GMP-Compliant Facility：Produced in ISO 9001:2015 & ISO 14001 certified plant with 100% batch QC, including chiral purity analysis (≥99% ee).
Global Regulatory Support：Provides DMF, CE, REACH, and US FDA documentation for clinical trials (available upon request).
Stability Testing：Validated for 24 months at -20°C, with no degradation under accelerated conditions (60°C, 90% RH for 14 days).
Structural Modifications：
Alternative alkyl chains (C6-C12), isotopic labeling (¹³C, ²H) for PK/PD studies.
Custom linker lengths (AEEA x1-x4) to optimize drug release profiles.
Scalable Production：
100 mg to 5 kg batches, with process validation for GMP-grade materials (≥98.5% purity).
Technical Consultation：
Free synthetic route optimization by our PhD-level peptide chemistry team (24-hour response).
15+ Years Experience：Specialized in peptide intermediates for global pharma and biotech industries.
R&D Capability：30+ scientists in a 2,000㎡ state-of-the-art laboratory.
Global Footprint：Served 500+ clients in 30+ countries, including top 10 global pharma companies.
Email：export@pu-kang.com
Phone：+86-137-0808-4407
Address：Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
PuKang Inc.
Zone 1 and 2, 1-3F, Building 3, Chengdu Cross-Strait Science and Technology Industrial Development Park [Jindi Weixin Wenjiang Intelligent Park], Wenjiang District, Chengdu, China.
Tel : +8613708084407
Business/Technical Consulting：
Tel : 008628-82550498 Tel : +8613708084407Order/Customer Service Email：
export@pu-kang.com celeste@pu-kang.com
+8613708084407
