Fmoc-His-Aib-OH·TFA, also known by its CAS number 1446013-08-6, is a custom-made peptide intermediate widely used in modern peptide drug design—especially in the synthesis of GLP-1 receptor agonists such as semaglutide.

At Chengdu Pukang Biotechnology Technology Co., Ltd., we offer this compound with high purity, suitable for pharmaceutical R&D and peptide assembly projects.

🔬 What is Fmoc-His-Aib-OH·TFA?

This molecule consists of:

• Fmoc: A protective group used in solid-phase peptide synthesis (SPPS).

• His (Histidine): A naturally occurring amino acid with an imidazole side chain.

• Aib (α-aminoisobutyric acid): A synthetic residue that enhances peptide stability.

• TFA (trifluoroacetate): Salt form that aids in purification and storage.

Together, it acts as a dipeptide unit—His-Aib—with Fmoc protection, ready for incorporation into larger peptide chains.

⚙️ Role in Peptide Drugs Like Semaglutide

Semaglutide and similar GLP-1 analogs include Aib to resist enzymatic degradation by DPP-4, thus improving drug stability and duration. Fmoc-His-Aib-OH·TFA is often used at the N-terminal end of such peptides.

Studies confirm that Aib substitution at position 2 dramatically improves the peptide’s resistance and half-life. This makes the compound essential in the pharmaceutical synthesis of next-gen diabetes and obesity treatments.

💧 Solubility & Storage

• Soluble in: DMF, DMSO, NMP (standard peptide synthesis solvents)

• Storage: –20 °C, sealed and moisture-free for long-term stability

🔎 Related Research & Further Reading

To understand its importance, we recommend:

• “Peptide Therapeutics” – Srivastava

• “Principles of Peptide Synthesis” – Bodanszky

These works highlight how small dipeptides like His-Aib serve as foundations for large-scale therapeutic innovations.

🧪 Available from Chengdu Pukang Biotechnology

Chengdu Pukang Biotechnology Technology Co., Ltd. is a reliable supplier of peptide building blocks, offering:

• High-purity products

• Flexible packaging for labs or pilot production

• Responsive global support

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Conclusion
If your research involves GLP-1 analogs or long-acting peptides, Fmoc-His-Aib-OH·TFA (CAS 1446013-08-6) is a smart choice. Trust Chengdu Pukang Biotechnology Technology Co., Ltd. for professional-grade peptide intermediates.