Pukang has constructed a polypeptide long-lasting modifier platform, which is a technology platform focusing on the long-lasting modification of peptide drugs. This platform usually utilizes chemical or biological means to modify peptide drugs to extend their half-life in vivo and improve the stability and bioavailability of the drugs, thus enhancing therapeutic effects and reducing the frequency of drug administration for patients.

Our company can provide customized service, and at the same time, can also provide  cas number 2061897-68-3, cas number 1446013-08-6, cas number 2639221-78-4, cas number 2171139-20-9, cas number 1890228-73-5, cas number 843666-40-0, cas number 878797-09-2, cas number 252554-78-2, cas number 878797-01-4.

The following is a detailed introduction to the polypeptide long-lasting modifier platform:

I. Platform Overview

The polypeptide long-lasting modifier platform is dedicated to the development and application of various peptide modification technologies to meet the needs of long-lasting different peptide drugs. These technologies include, but are not limited to, PEG modification, fatty acid modification, Fc fusion, glycosylation modification and so on. Through these modifications, the platform can significantly improve the in vivo stability, extend the half-life, and improve the pharmacokinetic properties of peptide drugs.

Main modification technologies

PEG modification: PEG (polyethylene glycol) is a hydrophilic polymer compound, which can increase the hydrodynamic radius of the drug and reduce the rate of glomerular filtration by connecting it to the peptide drug, thus prolonging the half-life of the drug, and PEG modification also improves the solubility and stability of the drug, and reduces the immunogenicity.

Fatty acid modification: Fatty acid modification is used to improve the cellular uptake efficiency and bioavailability of a drug by attaching a fatty acid to the N- or C-terminal end of a peptide drug so that it can bind to the cell membrane. This means of modification also enhances the targeting and tissue distribution properties of the drug.

Fc fusion: Fc fusion technology involves the fusion of a peptide drug with an immunoglobulin Fc fragment, which utilizes the Fc fragment's ability to bind to plasma proteins and extends the half-life of the drug. In addition, Fc fusion improves the stability and immunogenicity of the drug.

Glycosylation modification: Glycosylation modification is the coupling of oligosaccharides molecules to special functional groups of peptide drugs to prolong the half-life and improve the pharmacological properties of the drugs by increasing the spatial site resistance and improving the immunogenicity of the drugs.

Platform Advantages

Diversity of technologies: The platform of peptide long-lasting modifiers has a variety of modification technologies, and the most suitable modification means can be selected according to the characteristics and needs of different peptide drugs.

High efficiency: The platform adopts advanced synthesis and modification technologies, which can quickly and efficiently prepare long-lasting peptide drugs.

Customized service: The platform provides customized service, which can design and prepare long-acting peptide drugs with specific structure and function according to the specific needs of customers.

Quality Assurance: The platform has a perfect quality control system to ensure that the long-acting peptide drugs prepared by the platform meet the relevant standards and requirements.

Application Prospects

The platform of long-lasting polypeptide modifiers has a wide range of application prospects in the field of drug research and development. By modifying peptide drugs, their half-life, stability and bioavailability can be prolonged, thus enhancing therapeutic effects and reducing the frequency of patients' medication. In addition, this platform can provide strong technical support and guarantee for new drug development, and promote the continuous development and innovation of the pharmaceutical industry.

polypeptide long-lasting modifier platform is a technology platform focusing on the long-lasting modification of peptide drugs. Through the application of various modification technologies, the in vivo stability and half-life of peptide drugs can be significantly improved, and their pharmacokinetic properties can also be improved. This platform has a wide range of application prospects and important value in the field of drug discovery and development. For more information, please contact us.